Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso
Identifieur interne : 002135 ( Main/Exploration ); précédent : 002134; suivant : 002136Antiplasmodial activity of alkaloid extracts from Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC), two plants used in traditional medicine in Burkina Faso
Auteurs : S. Sanon [Burkina Faso] ; N. Azas [France] ; M. Gasquet [France] ; E. Ollivier [France] ; V. Mahiou [France] ; N. Barro [Burkina Faso] ; N. Cuzin-Ouattara [Burkina Faso] ; A. S. Traore [Burkina Faso] ; F. Esposito [Burkina Faso] ; G. Balansard [France] ; P. Timon-David [France]Source :
- Parasitology Research [ 0932-0113 ] ; 2003-07-01.
Abstract
Abstract: In the course of the search for new antimalarial compounds, a study of plants traditionally used against malaria in Burkina Faso was made. An ethnobotanical study permitted the identification of plants currently used by the traditional healers and herbalists. Two plants among them were selected for further study: Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC). Alkaloid extracts of these plants were tested in vitro against two reference clones of Plasmodium falciparum: the W2 chloroquine-resistant and the D6 chloroquine-sensitive strains. Significant inhibitory activity was observed with Pavetta crassipes (IC50=1.23 µg/ml) and A. hispidum (IC50=5.02 µg/ml). Antiplasmodial activity was also evaluated against six Plasmodium falciparum isolates from children between 4 and 10 years old. The IC50 values for the alkaloid extracts were in the range 25–670 ng/ml. These results indicated that P. falciparum wild strains were more sensitive to the alkaloid extracts than strains maintained in continuous culture. Moreover, the alkaloid extracts exhibit good in vitro antimalarial activity and weak cytotoxicity against three human cell lines (THP1, normal melanocytes, HTB-66). Isolation and structural determination are now necessary in order to precisely determine the active compounds.
Url:
DOI: 10.1007/s00436-003-0859-9
Affiliations:
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Timon-David</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Laboratory of Parasitology, Faculty of Pharmacy, University of the Mediterranean, 27 Bd Jean Moulin, 13385 cedex 5, Marseilles</wicri:regionArea><wicri:noRegion>Marseilles</wicri:noRegion><wicri:noRegion>Marseilles</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Parasitology Research</title><title level="j" type="abbrev">Parasitol Res</title><idno type="ISSN">0932-0113</idno><idno type="eISSN">1432-1955</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2003-07-01">2003-07-01</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="314">314</biblScope><biblScope unit="page" to="317">317</biblScope></imprint><idno type="ISSN">0932-0113</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0932-0113</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: In the course of the search for new antimalarial compounds, a study of plants traditionally used against malaria in Burkina Faso was made. An ethnobotanical study permitted the identification of plants currently used by the traditional healers and herbalists. Two plants among them were selected for further study: Pavetta crassipes (K. Schum) and Acanthospermum hispidum (DC). Alkaloid extracts of these plants were tested in vitro against two reference clones of Plasmodium falciparum: the W2 chloroquine-resistant and the D6 chloroquine-sensitive strains. Significant inhibitory activity was observed with Pavetta crassipes (IC50=1.23 µg/ml) and A. hispidum (IC50=5.02 µg/ml). Antiplasmodial activity was also evaluated against six Plasmodium falciparum isolates from children between 4 and 10 years old. The IC50 values for the alkaloid extracts were in the range 25–670 ng/ml. These results indicated that P. falciparum wild strains were more sensitive to the alkaloid extracts than strains maintained in continuous culture. Moreover, the alkaloid extracts exhibit good in vitro antimalarial activity and weak cytotoxicity against three human cell lines (THP1, normal melanocytes, HTB-66). Isolation and structural determination are now necessary in order to precisely determine the active compounds.</div></front></TEI><affiliations><list><country><li>Burkina Faso</li><li>France</li></country></list><tree><country name="Burkina Faso"><noRegion><name sortKey="Sanon, S" sort="Sanon, S" uniqKey="Sanon S" first="S." last="Sanon">S. Sanon</name></noRegion><name sortKey="Barro, N" sort="Barro, N" uniqKey="Barro N" first="N." last="Barro">N. Barro</name><name sortKey="Cuzin Ouattara, N" sort="Cuzin Ouattara, N" uniqKey="Cuzin Ouattara N" first="N." last="Cuzin-Ouattara">N. Cuzin-Ouattara</name><name sortKey="Esposito, F" sort="Esposito, F" uniqKey="Esposito F" first="F." last="Esposito">F. Esposito</name><name sortKey="Sanon, S" sort="Sanon, S" uniqKey="Sanon S" first="S." last="Sanon">S. Sanon</name><name sortKey="Traore, A S" sort="Traore, A S" uniqKey="Traore A" first="A. S." last="Traore">A. S. Traore</name></country><country name="France"><noRegion><name sortKey="Azas, N" sort="Azas, N" uniqKey="Azas N" first="N." last="Azas">N. Azas</name></noRegion><name sortKey="Balansard, G" sort="Balansard, G" uniqKey="Balansard G" first="G." last="Balansard">G. Balansard</name><name sortKey="Gasquet, M" sort="Gasquet, M" uniqKey="Gasquet M" first="M." last="Gasquet">M. Gasquet</name><name sortKey="Mahiou, V" sort="Mahiou, V" uniqKey="Mahiou V" first="V." last="Mahiou">V. Mahiou</name><name sortKey="Ollivier, E" sort="Ollivier, E" uniqKey="Ollivier E" first="E." last="Ollivier">E. Ollivier</name><name sortKey="Ollivier, E" sort="Ollivier, E" uniqKey="Ollivier E" first="E." last="Ollivier">E. Ollivier</name><name sortKey="Timon David, P" sort="Timon David, P" uniqKey="Timon David P" first="P." last="Timon-David">P. 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